1zq1

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[[Image:1zq1.gif|left|200px]]
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{{STRUCTURE_1zq1| PDB=1zq1 | SCENE= }}
{{STRUCTURE_1zq1| PDB=1zq1 | SCENE= }}
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'''Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi'''
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===Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi===
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==Overview==
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Besides direct charging of tRNAs by aminoacyl-tRNA synthetases, indirect routes also ensure attachment of some amino acids onto tRNA. Such routes may explain how new amino acids entered into protein synthesis. In archaea and in most bacteria, tRNA(Gln) is first misaminoacylated by glutamyl-tRNA synthetase. Glu-tRNA(Gln) is then matured into Gln-tRNA(Gln) by a tRNA-dependent amidotransferase. We report the structure of a tRNA-dependent amidotransferase-that of GatDE from Pyrococcus abyssi. The 3.0 A resolution crystal structure shows a tetramer with two GatD molecules as the core and two GatE molecules at the periphery. The fold of GatE cannot be related to that of any tRNA binding enzyme. The ammonium donor site on GatD and the tRNA site on GatE are markedly distant. Comparison of GatD and L-asparaginase structures shows how the motion of a beta hairpin region containing a crucial catalytic threonine may control the overall reaction cycle of GatDE.
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The line below this paragraph, {{ABSTRACT_PUBMED_16216574}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16216574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16216574}}
==About this Structure==
==About this Structure==
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[[Category: Gatd subfamily]]
[[Category: Gatd subfamily]]
[[Category: X-ray]]
[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:55:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:42:23 2008''

Revision as of 19:42, 27 July 2008

Image:1zq1.png

Template:STRUCTURE 1zq1

Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi

Template:ABSTRACT PUBMED 16216574

About this Structure

1ZQ1 is a Protein complex structure of sequences from Pyrococcus abyssi. Full crystallographic information is available from OCA.

Reference

Structural basis for tRNA-dependent amidotransferase function., Schmitt E, Panvert M, Blanquet S, Mechulam Y, Structure. 2005 Oct;13(10):1421-33. PMID:16216574

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