2pwt

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{{STRUCTURE_2pwt| PDB=2pwt | SCENE= }}
{{STRUCTURE_2pwt| PDB=2pwt | SCENE= }}
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'''Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group'''
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===Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group===
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==Overview==
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The crystal structure of the complex between oligonucleotide containing the bacterial ribosomal decoding site (A site) and the synthetic paromomycin analogue 1, which contains the gamma-amino-alpha-hydroxybutyryl (L-haba) group at position N1 of ring II (2-DOS ring), and an ether chain with an O-phenethylaminoethyl group at position C2'' of ring III, is reported. Interestingly, next to the paromomycin analogue 1 specifically bound to the A site, a second molecule of 1 with a different conformation is observed at the crystal packing interface which mimics the A-minor interaction between two bulged-out adenines from the A site and the codon-anticodon stem of the mRNA-tRNA complex. Improved antibacterial activity supports the conclusion that analogue 1 might affect protein synthesis on the ribosome in two different ways: 1) specific binding to the A site forces maintenance of the "on" state with two bulged out adenines, and 2) a new binding mode of 1 to an A-minor motif which stabilizes complex formation between the ribosome and the mRNA-tRNA complex regardless of whether the codon-anticodon stem is of the cognate or near-cognate type.
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(as it appears on PubMed at http://www.pubmed.gov), where 17722211 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17722211}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: X-ray analysis]]
[[Category: X-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:55:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:43:11 2008''

Revision as of 19:43, 27 July 2008

Image:2pwt.png

Template:STRUCTURE 2pwt

Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group

Template:ABSTRACT PUBMED 17722211

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity., Kondo J, Pachamuthu K, Francois B, Szychowski J, Hanessian S, Westhof E, ChemMedChem. 2007 Nov 12;2(11):1631-1638. PMID:17722211

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