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1tge

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[[Image:1tge.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1tge| PDB=1tge | SCENE= }}
{{STRUCTURE_1tge| PDB=1tge | SCENE= }}
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'''The structure of immature Dengue virus at 12.5 angstrom'''
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===The structure of immature Dengue virus at 12.5 angstrom===
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==Overview==
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Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
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The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15341726}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Prm particle]]
[[Category: Prm particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:55:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:45:37 2008''

Revision as of 19:45, 27 July 2008

Image:1tge.png

Template:STRUCTURE 1tge

The structure of immature Dengue virus at 12.5 angstrom

Template:ABSTRACT PUBMED 15341726

About this Structure

1TGE is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Conformational changes of the flavivirus E glycoprotein., Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG, Structure. 2004 Sep;12(9):1607-18. PMID:15341726

Page seeded by OCA on Sun Jul 27 22:45:37 2008

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