2hvz

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[[Image:2hvz.gif|left|200px]]
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{{STRUCTURE_2hvz| PDB=2hvz | SCENE= }}
{{STRUCTURE_2hvz| PDB=2hvz | SCENE= }}
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'''Solution structure of the RRM domain of SR rich factor 9G8'''
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===Solution structure of the RRM domain of SR rich factor 9G8===
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==Overview==
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The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.
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(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17036044}}
==About this Structure==
==About this Structure==
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2HVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA].
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2HVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA].
==Reference==
==Reference==
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[[Category: Wilson, S A.]]
[[Category: Wilson, S A.]]
[[Category: Rrm]]
[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:46:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:46:12 2008''

Revision as of 19:46, 27 July 2008

Image:2hvz.png

Template:STRUCTURE 2hvz

Solution structure of the RRM domain of SR rich factor 9G8

Template:ABSTRACT PUBMED 17036044

About this Structure

2HVZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8., Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH, EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:17036044

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