2fqe

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{{STRUCTURE_2fqe| PDB=2fqe | SCENE= }}
{{STRUCTURE_2fqe| PDB=2fqe | SCENE= }}
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'''Crystal Structures of E. coli Laccase CueO under different copper binding situations'''
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===Crystal Structures of E. coli Laccase CueO under different copper binding situations===
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==Overview==
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CueO protein is a hypothetical bacterial laccase and a good laccase candidate for large scale industrial application. Four CueO crystal structures were determined at different copper concentrations. Low copper occupancy in apo-CueO and slow copper reconstitution process in CueO with exogenous copper were demonstrated. These observations well explain the copper dependence of CueO oxidase activity. Structural comparison between CueO and other three fungal laccase proteins indicates that Glu106 in CueO constitutes the primary counter-work for reconstitution of the trinuclear copper site. Mutation of Glu106 to a Phe enhanced CueO oxidation activity and supported this hypothesis. In addition, an extra alpha-helix from Leu351 to Gly378 covers substrate biding pocket of CueO and might compromises the electron transfer from substrate to type I copper.
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(as it appears on PubMed at http://www.pubmed.gov), where 17217912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17217912}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
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[[Category: Azurin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:12:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:39 2008''

Revision as of 19:48, 27 July 2008

Image:2fqe.png

Template:STRUCTURE 2fqe

Crystal Structures of E. coli Laccase CueO under different copper binding situations

Template:ABSTRACT PUBMED 17217912

About this Structure

2FQE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of E. coli laccase CueO at different copper concentrations., Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W, Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912

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