1z60

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{{STRUCTURE_1z60| PDB=1z60 | SCENE= }}
{{STRUCTURE_1z60| PDB=1z60 | SCENE= }}
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'''Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit'''
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===Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit===
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==Overview==
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The human general transcription factor TFIIH is involved in both transcription and DNA nucleotide excision repair. Among the 10 subunits of the complex, p44 subunit plays a crucial role in both mechanisms. Its N-terminal domain interacts with the XPD helicase, whereas its C-terminal domain is involved specifically in the promoter escape activity. By mutating an exposed and non-conserved cysteine residue into a serine, we produced a soluble mutant of p44-(321-395) suitable for solution structure determination. The domain adopts a C4C4 RING domain structure with sequential organization of beta-strands that is related to canonical RING domains by a circular permutation of the beta-sheet elements. Analysis of the molecular surface and mutagenesis experiments suggests that the binding of p44-(321-395) to TFIIH p34 subunit is not mediated by electrostatic interactions and, thus, differs from previously reported interaction mechanisms involving RING domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 15790571 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15790571}}
==About this Structure==
==About this Structure==
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1Z60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e53 1e53]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z60 OCA].
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1Z60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e53 1e53]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z60 OCA].
==Reference==
==Reference==
Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions., Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B, J Biol Chem. 2005 May 27;280(21):20785-92. Epub 2005 Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15790571 15790571]
Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions., Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B, J Biol Chem. 2005 May 27;280(21):20785-92. Epub 2005 Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15790571 15790571]
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Structural characterization of the cysteine-rich domain of TFIIH p44 subunit., Fribourg S, Kellenberger E, Rogniaux H, Poterszman A, Van Dorsselaer A, Thierry JC, Egly JM, Moras D, Kieffer B, J Biol Chem. 2000 Oct 13;275(41):31963-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882739 10882739]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Ring finger]]
[[Category: Ring finger]]
[[Category: Zinc binding protein]]
[[Category: Zinc binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:12:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:52:36 2008''

Revision as of 19:52, 27 July 2008

Image:1z60.png

Template:STRUCTURE 1z60

Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit

Template:ABSTRACT PUBMED 15790571

About this Structure

1Z60 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1e53. Full experimental information is available from OCA.

Reference

Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions., Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B, J Biol Chem. 2005 May 27;280(21):20785-92. Epub 2005 Mar 24. PMID:15790571

Structural characterization of the cysteine-rich domain of TFIIH p44 subunit., Fribourg S, Kellenberger E, Rogniaux H, Poterszman A, Van Dorsselaer A, Thierry JC, Egly JM, Moras D, Kieffer B, J Biol Chem. 2000 Oct 13;275(41):31963-71. PMID:10882739

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