1wnh

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{{STRUCTURE_1wnh| PDB=1wnh | SCENE= }}
{{STRUCTURE_1wnh| PDB=1wnh | SCENE= }}
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'''Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)'''
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===Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)===
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==Overview==
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Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors. Furthermore, despite a lack of detectable sequence duplication, the structure incorporates two topologically analogous domains related by pseudo two-fold symmetry. Surprisingly, these domains share a cystatin fold architecture found in proteins that inhibit cysteine proteases, suggesting an evolutionary and possibly functional relationship. The structure of the tumor suppressor protein TIG1 was modeled, revealing its putative membrane binding surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 15698574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15698574}}
==About this Structure==
==About this Structure==
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[[Category: Bi-cystatin fold]]
[[Category: Bi-cystatin fold]]
[[Category: Cis-proline]]
[[Category: Cis-proline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:54:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:54:08 2008''

Revision as of 19:54, 27 July 2008

Image:1wnh.png

Template:STRUCTURE 1wnh

Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)

Template:ABSTRACT PUBMED 15698574

About this Structure

1WNH is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1., Aagaard A, Listwan P, Cowieson N, Huber T, Ravasi T, Wells CA, Flanagan JU, Kellie S, Hume DA, Kobe B, Martin JL, Structure. 2005 Feb;13(2):309-17. PMID:15698574

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