1zhu

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[[Image:1zhu.gif|left|200px]]
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{{Seed}}
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[[Image:1zhu.png|left|200px]]
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{{STRUCTURE_1zhu| PDB=1zhu | SCENE= }}
{{STRUCTURE_1zhu| PDB=1zhu | SCENE= }}
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'''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES'''
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===DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES===
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==Overview==
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In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases.
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The line below this paragraph, {{ABSTRACT_PUBMED_7583654}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7583654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7583654}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHU OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHU OCA].
==Reference==
==Reference==
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[[Category: Single residue loop]]
[[Category: Single residue loop]]
[[Category: Triplet disease]]
[[Category: Triplet disease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:38:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:58:34 2008''

Revision as of 19:58, 27 July 2008

Image:1zhu.png

Template:STRUCTURE 1zhu

DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 7583654

About this Structure

Full experimental information is available from OCA.

Reference

Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654

Page seeded by OCA on Sun Jul 27 22:58:34 2008

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