1jwt

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{{STRUCTURE_1jwt| PDB=1jwt | SCENE= }}
{{STRUCTURE_1jwt| PDB=1jwt | SCENE= }}
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'''CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR'''
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===CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR===
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==Overview==
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Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 11720865 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11720865}}
==About this Structure==
==About this Structure==
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[[Category: Winocour, P D.]]
[[Category: Winocour, P D.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:08:30 2008''

Revision as of 20:08, 27 July 2008

Template:STRUCTURE 1jwt

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR

Template:ABSTRACT PUBMED 11720865

About this Structure

1JWT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues., Levesque S, St-Denis Y, Bachand B, Preville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA, Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. PMID:11720865

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