1n0j

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{{STRUCTURE_1n0j| PDB=1n0j | SCENE= }}
{{STRUCTURE_1n0j| PDB=1n0j | SCENE= }}
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'''The Structure of Human Mitochondrial MN3+ Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-Helix Bundles'''
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===The Structure of Human Mitochondrial MN3+ Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-Helix Bundles===
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==Overview==
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The 2.2 A resolution crystal structure of recombinant human manganese superoxide dismutase, a homotetrameric enzyme that protects mitochondria against oxygen-mediated free radical damage, has been determined. Within each subunit, both the N-terminal helical hairpin and C-terminal alpha/beta domains contribute ligands to the catalytic manganese site. Two identical 4-helix bundles, symmetrically assembled from the N-terminal helical hairpins, form novel tetrameric interfaces that stabilize the active sites. Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
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(as it appears on PubMed at http://www.pubmed.gov), where 1394426 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1394426}}
==About this Structure==
==About this Structure==
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[[Category: Manganese]]
[[Category: Manganese]]
[[Category: Metalloenzyme]]
[[Category: Metalloenzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:09:15 2008''

Revision as of 20:09, 27 July 2008

Image:1n0j.png

Template:STRUCTURE 1n0j

The Structure of Human Mitochondrial MN3+ Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-Helix Bundles

Template:ABSTRACT PUBMED 1394426

About this Structure

1N0J is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1abm. Full crystallographic information is available from OCA.

Reference

The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles., Borgstahl GE, Parge HE, Hickey MJ, Beyer WF Jr, Hallewell RA, Tainer JA, Cell. 1992 Oct 2;71(1):107-18. PMID:1394426

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