1xyu

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[[Image:1xyu.gif|left|200px]]
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{{STRUCTURE_1xyu| PDB=1xyu | SCENE= }}
{{STRUCTURE_1xyu| PDB=1xyu | SCENE= }}
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'''Solution structure of the sheep prion protein with polymorphism H168'''
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===Solution structure of the sheep prion protein with polymorphism H168===
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==Overview==
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The NMR structures of the recombinant cellular form of the prion proteins (PrPC) of the cat (Felis catus), dog (Canis familiaris), and pig (Sus scrofa), and of two polymorphic forms of the prion protein from sheep (Ovis aries) are presented. In all of these species, PrPC consists of an N-terminal flexibly extended tail with approximately 100 amino acid residues and a C-terminal globular domain of approximately 100 residues with three alpha-helices and a short antiparallel beta-sheet. Although this global architecture coincides with the previously reported murine, Syrian hamster, bovine, and human PrPC structures, there are local differences between the globular domains of the different species. Because the five newly determined PrPC structures originate from species with widely different transmissible spongiform encephalopathy records, the present data indicate previously uncharacterized possible correlations between local features in PrPC three-dimensional structures and susceptibility of different mammalian species to transmissible spongiform encephalopathies.
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The line below this paragraph, {{ABSTRACT_PUBMED_15647367}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15647367 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15647367}}
==About this Structure==
==About this Structure==
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1XYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYU OCA].
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1XYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYU OCA].
==Reference==
==Reference==
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[[Category: Prp]]
[[Category: Prp]]
[[Category: Tse]]
[[Category: Tse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:40:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:11:48 2008''

Revision as of 20:11, 27 July 2008

Image:1xyu.png

Template:STRUCTURE 1xyu

Solution structure of the sheep prion protein with polymorphism H168

Template:ABSTRACT PUBMED 15647367

About this Structure

1XYU is a Single protein structure of sequence from Ovis aries. Full experimental information is available from OCA.

Reference

Prion protein NMR structures of cats, dogs, pigs, and sheep., Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, von Schroetter C, Fiorito F, Herrmann T, Guntert P, Wuthrich K, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. Epub 2005 Jan 12. PMID:15647367

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