2fey

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[[Image:2fey.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fey| PDB=2fey | SCENE= }}
{{STRUCTURE_2fey| PDB=2fey | SCENE= }}
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'''The structure of stem loop IV of Tetrahymena telomerase RNA'''
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===The structure of stem loop IV of Tetrahymena telomerase RNA===
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==Overview==
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Conserved domains within the RNA component of telomerase provide the template for reverse transcription, recruit protein components to the holoenzyme and are required for enzymatic activity. Among the functionally essential domains in ciliate telomerase RNA is stem-loop IV, which strongly stimulates telomerase activity and processivity even when provided in trans. The NMR structure of Tetrahymena thermophila stem-loop IV shows a highly structured distal stem-loop linked to a conformationally flexible template-proximal region by a bulge that severely kinks the entire RNA. Through extensive structure-function studies, we identify residues that contribute to both these structural features and to enzymatic activity, with no apparent effect on the binding of TERT protein. We propose that the bending induced by the GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured apical loop during the catalytic cycle.
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The line below this paragraph, {{ABSTRACT_PUBMED_16778765}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16778765 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16778765}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEY OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEY OCA].
==Reference==
==Reference==
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[[Category: Telomerase rna]]
[[Category: Telomerase rna]]
[[Category: Tetrahymena]]
[[Category: Tetrahymena]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:48:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:11:47 2008''

Revision as of 20:11, 27 July 2008

Image:2fey.png

Template:STRUCTURE 2fey

The structure of stem loop IV of Tetrahymena telomerase RNA

Template:ABSTRACT PUBMED 16778765

About this Structure

Full experimental information is available from OCA.

Reference

Structure of stem-loop IV of Tetrahymena telomerase RNA., Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G, EMBO J. 2006 Jul 12;25(13):3156-66. Epub 2006 Jun 15. PMID:16778765

Page seeded by OCA on Sun Jul 27 23:11:47 2008

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