1pv8

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{{STRUCTURE_1pv8| PDB=1pv8 | SCENE= }}
{{STRUCTURE_1pv8| PDB=1pv8 | SCENE= }}
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'''Crystal structure of a low activity F12L mutant of human phorphobilinogen synthase'''
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===Crystal structure of a low activity F12L mutant of human phorphobilinogen synthase===
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==Overview==
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Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of tetrapyrroles (such as heme and chlorophyll). Although the predominant oligomeric form of this enzyme, as inferred from many crystal structures, is that of a homo-octamer, a rare human PBGS allele, F12L, reveals the presence of a hexameric form. Rearrangement of an N-terminal arm is responsible for this oligomeric switch, which results in profound changes in kinetic behavior. The structural transition between octamer and hexamer must proceed through an unparalleled equilibrium containing two different dimer structures. The allosteric magnesium, present in most PBGS, has a binding site in the octamer but not in the hexamer. The unprecedented structural rearrangement reported here relates to the allosteric regulation of PBGS and suggests that alternative PBGS oligomers may function in a magnesium-dependent regulation of tetrapyrrole biosynthesis in plants and some bacteria.
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(as it appears on PubMed at http://www.pubmed.gov), where 12897770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12897770}}
==Disease==
==Disease==
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[[Category: Reaction intermediate]]
[[Category: Reaction intermediate]]
[[Category: Tetrapyrrole biosynthesis]]
[[Category: Tetrapyrrole biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:12:43 2008''

Revision as of 20:12, 27 July 2008

Image:1pv8.png

Template:STRUCTURE 1pv8

Contents

Crystal structure of a low activity F12L mutant of human phorphobilinogen synthase

Template:ABSTRACT PUBMED 12897770

Disease

Known disease associated with this structure: Porphyria, acute hepatic OMIM:[125270], Lead poisoning, susceptibility to OMIM:[125270]

About this Structure

1PV8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase., Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK, Nat Struct Biol. 2003 Sep;10(9):757-63. Epub 2003 Aug 3. PMID:12897770

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