1qo3

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[[Image:1qo3.gif|left|200px]]
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{{STRUCTURE_1qo3| PDB=1qo3 | SCENE= }}
{{STRUCTURE_1qo3| PDB=1qo3 | SCENE= }}
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'''COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD'''
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===COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD===
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==Overview==
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Natural killer (NK) cell function is regulated by NK receptors that interact with MHC class I (MHC-I) molecules on target cells. The murine NK receptor Ly49A inhibits NK cell activity by interacting with H-2D(d) through its C-type-lectin-like NK receptor domain. Here we report the crystal structure of the complex between the Ly49A NK receptor domain and unglycosylated H-2D(d). The Ly49A dimer interacts extensively with two H-2D(d) molecules at distinct sites. At one interface, a single Ly49A subunit contacts one side of the MHC-I peptide-binding platform, presenting an open cavity towards the conserved glycosylation site on the H-2D(d) alpha2 domain. At a second, larger interface, the Ly49A dimer binds in a region overlapping the CD8-binding site. The smaller interface probably represents the interaction between Ly49A on the NK cell and MHC-I on the target cell, whereas the larger one suggests an interaction between Ly49A and MHC-I on the NK cell itself. Both Ly49A binding sites on MHC-I are spatially distinct from that of the T-cell receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 10604468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10604468}}
==About this Structure==
==About this Structure==
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[[Category: Mhc-i]]
[[Category: Mhc-i]]
[[Category: Nk cell]]
[[Category: Nk cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:30:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:13:27 2008''

Revision as of 20:13, 27 July 2008

Image:1qo3.png

Template:STRUCTURE 1qo3

COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD

Template:ABSTRACT PUBMED 10604468

About this Structure

1QO3 is a Protein complex structure of sequences from Human immunodeficiency virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand., Tormo J, Natarajan K, Margulies DH, Mariuzza RA, Nature. 1999 Dec 9;402(6762):623-31. PMID:10604468

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