1x7r

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[[Image:1x7r.gif|left|200px]]
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{{Seed}}
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[[Image:1x7r.png|left|200px]]
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{{STRUCTURE_1x7r| PDB=1x7r | SCENE= }}
{{STRUCTURE_1x7r| PDB=1x7r | SCENE= }}
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'''CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN'''
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===CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN===
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==Overview==
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We present X-ray crystallographic and molecular modeling studies of estrogen receptors-alpha and -beta complexed with the estrogen receptor-beta-selective phytoestrogen genistein, and coactivator-derived NR box peptides containing an LXXLL motif. We demonstrate that the ligand binding mode is essentially identical when genistein is bound to both isoforms, despite the considerably weaker affinity of this ligand for estrogen receptor-alpha. In addition, we examine subtle differences between binding site residues, providing an explanation for why genistein is modestly selective for the beta isoform. To this end, we also present the results of quantum chemical studies and thermodynamic arguments that yield insight to the nature of the interactions leading to estrogen receptor-beta selectivity. The importance of our analysis to structure-based drug design is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15576033 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576033}}
==About this Structure==
==About this Structure==
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[[Category: Estrogen receptor beta]]
[[Category: Estrogen receptor beta]]
[[Category: Nuclear recept transcription factor]]
[[Category: Nuclear recept transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:40:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:14:07 2008''

Revision as of 20:14, 27 July 2008

Image:1x7r.png

Template:STRUCTURE 1x7r

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN

Template:ABSTRACT PUBMED 15576033

About this Structure

1X7R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods., Manas ES, Xu ZB, Unwalla RJ, Somers WS, Structure. 2004 Dec;12(12):2197-207. PMID:15576033

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