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2tbd

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{{STRUCTURE_2tbd| PDB=2tbd | SCENE= }}
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'''SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES'''
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===SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES===
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==Overview==
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The structure of the domain from simian virus 40 (SV40) large T-antigen that binds to the SV40 origin of DNA replication (T-ag-OBD131-260) has been determined by nuclear magnetic resonance spectroscopy. The overall fold, consisting of a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other, is a new one. Previous mutational analyses have identified two elements, termed A (approximately 152-155) and B2 (203-207), as essential for origin-specific recognition. These elements form two closely juxtaposed loops that define a continuous surface on the protein. The addition of a duplex oligonucleotide containing the origin recognition pentanucleotide GAGGC induces chemical shift changes and slows amide proton exchange in resonances from this region, indicating that this surface directly contacts the DNA.
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{{ABSTRACT_PUBMED_8946857}}
==About this Structure==
==About this Structure==
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2TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA].
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2TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA].
==Reference==
==Reference==
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[[Category: Origin-binding domain]]
[[Category: Origin-binding domain]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:22:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:16:07 2008''

Revision as of 20:16, 27 July 2008

Image:2tbd.png

Template:STRUCTURE 2tbd

SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 8946857

About this Structure

2TBD is a Single protein structure of sequence from Simian virus 40. Full experimental information is available from OCA.

Reference

Solution structure of the origin DNA-binding domain of SV40 T-antigen., Luo X, Sanford DG, Bullock PA, Bachovchin WW, Nat Struct Biol. 1996 Dec;3(12):1034-9. PMID:8946857

Page seeded by OCA on Sun Jul 27 23:16:07 2008

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