3ncm
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(New page: 200px<br /><applet load="3ncm" size="450" color="white" frame="true" align="right" spinBox="true" caption="3ncm" /> '''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR...)
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Revision as of 17:46, 20 November 2007
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NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES
Overview
The structure in solution of the second Ig-module fragment of residues, 117-208 of NCAM has been determined. Like the first Ig-module of residues, 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1, and module 2 interact weakly, and the binding sites of this interaction, have been identified. The two-module fragment NCAM(20-208) is a stable, dimer. Removal of the charged residues in these sites in NCAM(20-208), abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the, interactions of these charges produces one coherent binding site for the, formation of two antiparallel strands of the first two NCAM modules. This, mode of binding could be a major element in trans-cellular interactions in, neural cell adhesion.
About this Structure
3NCM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion., Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM, Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878
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