2a5y

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[[Image:2a5y.gif|left|200px]]
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{{Seed}}
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[[Image:2a5y.png|left|200px]]
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{{STRUCTURE_2a5y| PDB=2a5y | SCENE= }}
{{STRUCTURE_2a5y| PDB=2a5y | SCENE= }}
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'''Structure of a CED-4/CED-9 complex'''
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===Structure of a CED-4/CED-9 complex===
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==Overview==
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Interplay among four genes--egl-1, ced-9, ced-4 and ced-3--controls the onset of programmed cell death in the nematode Caenorhabditis elegans. Activation of the cell-killing protease CED-3 requires CED-4. However, CED-4 is constitutively inhibited by CED-9 until its release by EGL-1. Here we report the crystal structure of the CED-4-CED-9 complex at 2.6 A resolution, and a complete reconstitution of the CED-3 activation pathway using homogeneous proteins of CED-4, CED-9 and EGL-1. One molecule of CED-9 binds to an asymmetric dimer of CED-4, but specifically recognizes only one of the two CED-4 molecules. This specific interaction prevents CED-4 from activating CED-3. EGL-1 binding induces pronounced conformational changes in CED-9 that result in the dissociation of the CED-4 dimer from CED-9. The released CED-4 dimer further dimerizes to form a tetramer, which facilitates the autoactivation of CED-3. Together, our studies provide important insights into the regulation of cell death activation in C. elegans.
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The line below this paragraph, {{ABSTRACT_PUBMED_16208361}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16208361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16208361}}
==About this Structure==
==About this Structure==
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[[Category: Ced-4]]
[[Category: Ced-4]]
[[Category: Ced-9]]
[[Category: Ced-9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:38:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:21:55 2008''

Revision as of 20:22, 27 July 2008

Image:2a5y.png

Template:STRUCTURE 2a5y

Structure of a CED-4/CED-9 complex

Template:ABSTRACT PUBMED 16208361

About this Structure

2A5Y is a Protein complex structure of sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans., Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y, Nature. 2005 Oct 6;437(7060):831-7. PMID:16208361

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