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397d

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{{Seed}}
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{{STRUCTURE_397d| PDB=397d | SCENE= }}
{{STRUCTURE_397d| PDB=397d | SCENE= }}
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'''A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION'''
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===A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION===
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==Overview==
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The crystal structure of an HIV-1 trans-activation response region (TAR) RNA fragment containing the binding site for the trans-activation protein Tat has been determined to 1.3-A resolution. In this crystal structure, the characteristic UCU bulge of TAR adopts a conformation that is stabilized by three divalent calcium ions and differs from those determined previously by solution NMR. One metal ion, crucial to the loop conformation, binds directly to three phosphates in the loop region. The structure emphasizes the influence of metal ion binding on RNA structure and, given the abundance of divalent metal ion in the cell, raises the question of whether metal ions play a role in the conformation of TAR RNA and the interaction of TAR with Tat and cyclin T in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_9707559}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9707559 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9707559}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Overhanging base]]
[[Category: Overhanging base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:18:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:27:43 2008''

Revision as of 20:27, 27 July 2008

Image:397d.png

Template:STRUCTURE 397d

A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION

Template:ABSTRACT PUBMED 9707559

About this Structure

Full crystallographic information is available from OCA.

Reference

A 1.3-A resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation., Ippolito JA, Steitz TA, Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9819-24. PMID:9707559

Page seeded by OCA on Sun Jul 27 23:27:43 2008

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