1ub1

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[[Image:1ub1.gif|left|200px]]
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{{STRUCTURE_1ub1| PDB=1ub1 | SCENE= }}
{{STRUCTURE_1ub1| PDB=1ub1 | SCENE= }}
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'''Solution structure of the matrix attachment region-binding domain of chicken MeCP2'''
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===Solution structure of the matrix attachment region-binding domain of chicken MeCP2===
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==Overview==
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Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional protein involved in chromatin organization and silencing of methylated DNA. MAR-BD, a 125-amino-acid residue domain of chicken MeCP2 (cMeCP2, originally named ARBP), is the minimal protein fragment required to recognize MAR elements and mouse satellite DNA. Here we report the solution structure of MAR-BD as determined by multidimensional heteronuclear NMR spectroscopy. The global fold of this domain is very similar to that of rat MeCP2 MBD and MBD1 MBD (the methyl-CpG-binding domains of rat MeCP2 and methyl-CpG-binding domain protein 1, respectively), exhibiting a three-stranded antiparallel beta-sheet and an alpha-helix alpha1. We show that the C-terminal portion of MAR-BD also contains an amphipathic helical coil, alpha2/alpha3. The hydrophilic residues of this coil form a surface opposite the DNA interface, available for interactions with other domains of MeCP2 or other proteins. Spectroscopic studies of the complex formed by MAR-BD and a 15-bp fragment of a high-affinity binding site from mouse satellite DNA indicates that the coil is also involved in protein.DNA interactions. These studies provide a basis for discussion of the consequences of six missense mutations within the helical coil found in Rett syndrome cases.
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(as it appears on PubMed at http://www.pubmed.gov), where 12869202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12869202}}
==About this Structure==
==About this Structure==
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1UB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UB1 OCA].
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1UB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UB1 OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:29:21 2008''

Revision as of 20:29, 27 July 2008

Image:1ub1.png

Template:STRUCTURE 1ub1

Solution structure of the matrix attachment region-binding domain of chicken MeCP2

Template:ABSTRACT PUBMED 12869202

About this Structure

1UB1 is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Solution structure of the matrix attachment region-binding domain of chicken MeCP2., Heitmann B, Maurer T, Weitzel JM, Stratling WH, Kalbitzer HR, Brunner E, Eur J Biochem. 2003 Aug;270(15):3263-70. PMID:12869202

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