2ost

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[[Image:2ost.gif|left|200px]]
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{{STRUCTURE_2ost| PDB=2ost | SCENE= }}
{{STRUCTURE_2ost| PDB=2ost | SCENE= }}
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'''The structure of a bacterial homing endonuclease : I-Ssp6803I'''
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===The structure of a bacterial homing endonuclease : I-Ssp6803I===
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==Overview==
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The homing endonuclease I-Ssp6803I causes the insertion of a group I intron into a bacterial tRNA gene-the only example of an invasive mobile intron within a bacterial genome. Using a computational fold prediction, mutagenic screen and crystal structure determination, we demonstrate that this protein is a tetrameric PD-(D/E)-XK endonuclease - a fold normally used to protect a bacterial genome from invading DNA through the action of restriction endonucleases. I-Ssp6803I uses its tetrameric assembly to promote recognition of a single long target site, whereas restriction endonuclease tetramers facilitate cooperative binding and cleavage of two short sites. The limited use of the PD-(D/E)-XK nucleases by mobile introns stands in contrast to their frequent use of LAGLIDADG and HNH endonucleases - which in turn, are rarely incorporated into restriction/modification systems.
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(as it appears on PubMed at http://www.pubmed.gov), where 17410205 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17410205}}
==About this Structure==
==About this Structure==
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[[Category: Homing endonuclease]]
[[Category: Homing endonuclease]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:35:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:29:41 2008''

Revision as of 20:29, 27 July 2008

Image:2ost.png

Template:STRUCTURE 2ost

The structure of a bacterial homing endonuclease : I-Ssp6803I

Template:ABSTRACT PUBMED 17410205

About this Structure

2OST is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif., Zhao L, Bonocora RP, Shub DA, Stoddard BL, EMBO J. 2007 May 2;26(9):2432-42. Epub 2007 Apr 5. PMID:17410205

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