1qdn

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{{STRUCTURE_1qdn| PDB=1qdn | SCENE= }}
{{STRUCTURE_1qdn| PDB=1qdn | SCENE= }}
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'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''
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===AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)===
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==Overview==
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The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 10559905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10559905}}
==About this Structure==
==About this Structure==
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[[Category: Double-psi beta barrel alpha/beta barrel]]
[[Category: Double-psi beta barrel alpha/beta barrel]]
[[Category: Vesicular-fusion protein]]
[[Category: Vesicular-fusion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:09:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:32:02 2008''

Revision as of 20:32, 27 July 2008

Image:1qdn.png

Template:STRUCTURE 1qdn

AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)

Template:ABSTRACT PUBMED 10559905

About this Structure

1QDN is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905

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