1qxm

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{{Seed}}
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{{STRUCTURE_1qxm| PDB=1qxm | SCENE= }}
{{STRUCTURE_1qxm| PDB=1qxm | SCENE= }}
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'''Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum'''
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===Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum===
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==Overview==
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Botulism food poisoning is caused primarily by ingestion of the Clostridium botulinum neurotoxin (BoNT). The 1300 amino acid BoNT forms a progenitor toxin (PTX) that, when associated with a number of other proteins, increases its oral toxicity by protecting it from the low pH of the stomach and from intestinal proteases. One of these associated proteins, HA1, has also been suggested to be involved with internalization of the toxin into the bloodstream by binding to oligosaccharides lining the intestine. Here is reported the crystal structure of HA1 from type C Clostridium botulinum at a resolution of 1.7 Angstrom. The protein consists of two beta-trefoil domains and bears structural similarities to the lectin B-chain from the deadly plant toxin ricin. Based on structural comparison to the ricin B-chain lactose-binding sites, residues of type A HA1 were selected and mutated. The D263A and N285A mutants lost the ability to bind carbohydrates containing galactose moieties, implicating these residues in carbohydrate binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_14663070}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14663070 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14663070}}
==About this Structure==
==About this Structure==
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[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
[[Category: Trefoil]]
[[Category: Trefoil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:49:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:32:32 2008''

Revision as of 20:32, 27 July 2008

Image:1qxm.png

Template:STRUCTURE 1qxm

Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum

Template:ABSTRACT PUBMED 14663070

About this Structure

1QXM is a Single protein structure of sequence from Clostridium botulinum d phage. Full crystallographic information is available from OCA.

Reference

Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum., Inoue K, Sobhany M, Transue TR, Oguma K, Pedersen LC, Negishi M, Microbiology. 2003 Dec;149(Pt 12):3361-70. PMID:14663070

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