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1sz0

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[[Image:1sz0.gif|left|200px]]
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{{Seed}}
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[[Image:1sz0.png|left|200px]]
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{{STRUCTURE_1sz0| PDB=1sz0 | SCENE= }}
{{STRUCTURE_1sz0| PDB=1sz0 | SCENE= }}
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'''N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate'''
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===N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate===
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==Overview==
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The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the lysosome. The receptor contains two high affinity carbohydrate recognition sites within its 15-domain extracytoplasmic region, with essential residues for carbohydrate recognition located in domain 3 and domain 9. Previous studies have shown that these two sites are distinct with respect to carbohydrate specificity. In addition, expression of truncated forms of the CI-MPR demonstrated that domain 9 can be expressed as an isolated domain, retaining high affinity (Kd approximately 1 nm) carbohydrate binding, whereas expression of domain 3 alone resulted in a protein capable of only low affinity binding (Kd approximately 1 microm) toward a lysosomal enzyme. In the current report the crystal structure of the N-terminal 432 residues of the CI-MPR, encompassing domains 1-3, was solved in the presence of bound mannose 6-phosphate. The structure reveals the unique architecture of this carbohydrate binding pocket and provides insight into the ability of this site to recognize a variety of mannose-containing sugars.
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The line below this paragraph, {{ABSTRACT_PUBMED_15169779}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15169779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15169779}}
==About this Structure==
==About this Structure==
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[[Category: Mannose 6-phosphate]]
[[Category: Mannose 6-phosphate]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:33:22 2008''

Revision as of 20:33, 27 July 2008

Image:1sz0.png

Template:STRUCTURE 1sz0

N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate

Template:ABSTRACT PUBMED 15169779

About this Structure

1SZ0 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor., Olson LJ, Dahms NM, Kim JJ, J Biol Chem. 2004 Aug 6;279(32):34000-9. Epub 2004 May 28. PMID:15169779

Page seeded by OCA on Sun Jul 27 23:33:22 2008

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