1wv4

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{{STRUCTURE_1wv4| PDB=1wv4 | SCENE= }}
{{STRUCTURE_1wv4| PDB=1wv4 | SCENE= }}
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'''X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form'''
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===X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form===
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==Overview==
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Escherichia coli pyridoxine 5'-phosphate oxidase (ePNPOx) catalyzes the terminal step in the biosynthesis of pyridoxal 5'-phosphate (PLP) by the FMN oxidation of pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP), forming FMNH(2) and H(2)O(2). The crystal structure of ePNPOx is reported in a tetragonal unit cell at 2.6 A resolution. The three-dimensional fold of this structure is very similar to those of the E. coli and human enzymes that crystallized in trigonal and monoclinic unit cells. However, unlike the previous structures, the tetragonal structure shows major disorder in one of the two subunit domains that has opened up both the active site and a putative tunnel. Comparison of these structures gives an insight into the mechanistic pathway of PNPOx: from the resting enzyme with no substrate bound, to the initial binding of the substrate at the active site, to the catalytic stage and to the release of the catalytic product from the active site.
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{{ABSTRACT_PUBMED_15858270}}
==About this Structure==
==About this Structure==
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[[Category: Pyridoxal]]
[[Category: Pyridoxal]]
[[Category: Pyridoxine 5'-phosphate]]
[[Category: Pyridoxine 5'-phosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:10:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:35:46 2008''

Revision as of 20:35, 27 July 2008

Image:1wv4.png

Template:STRUCTURE 1wv4

X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form

Template:ABSTRACT PUBMED 15858270

About this Structure

1WV4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme., Safo MK, Musayev FN, Schirch V, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):599-604. Epub 2005, Apr 20. PMID:15858270

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