2i1r

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{{STRUCTURE_2i1r| PDB=2i1r | SCENE= }}
{{STRUCTURE_2i1r| PDB=2i1r | SCENE= }}
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'''Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure'''
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===Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure===
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==Overview==
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Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2A, and confirmed the design.
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{{ABSTRACT_PUBMED_17049849}}
==About this Structure==
==About this Structure==
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[[Category: Rdrp]]
[[Category: Rdrp]]
[[Category: Viral rna-directed rna polymerase]]
[[Category: Viral rna-directed rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:58:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:36:43 2008''

Revision as of 20:36, 27 July 2008

Template:STRUCTURE 2i1r

Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure

Template:ABSTRACT PUBMED 17049849

About this Structure

2I1R is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure., Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. Epub 2006 Oct 4. PMID:17049849

Page seeded by OCA on Sun Jul 27 23:36:43 2008

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