1v4t

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{{STRUCTURE_1v4t| PDB=1v4t | SCENE= }}
{{STRUCTURE_1v4t| PDB=1v4t | SCENE= }}
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'''Crystal structure of human glucokinase'''
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===Crystal structure of human glucokinase===
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==Overview==
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Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. The molecular basis for these two properties is not well understood. Herein we report the crystal structures of glucokinase in its active and inactive forms, which demonstrate that global conformational change, including domain reorganization, is induced by glucose binding. This suggests that the positive cooperativity of monomeric glucokinase obeys the "mnemonical mechanism" rather than the well-known concerted model. These structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.
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(as it appears on PubMed at http://www.pubmed.gov), where 15016359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15016359}}
==About this Structure==
==About this Structure==
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[[Category: Diabetes]]
[[Category: Diabetes]]
[[Category: Hexokinase iv]]
[[Category: Hexokinase iv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:04:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:38:09 2008''

Revision as of 20:38, 27 July 2008

Image:1v4t.png

Template:STRUCTURE 1v4t

Crystal structure of human glucokinase

Template:ABSTRACT PUBMED 15016359

About this Structure

1V4T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase., Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y, Structure. 2004 Mar;12(3):429-38. PMID:15016359

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