This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




2pon

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2pon.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2pon.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2pon| PDB=2pon | SCENE= }}
{{STRUCTURE_2pon| PDB=2pon | SCENE= }}
-
'''Solution structure of the Bcl-xL/Beclin-1 complex'''
+
===Solution structure of the Bcl-xL/Beclin-1 complex===
-
==Overview==
+
<!--
-
Beclin-1, originally identified as a Bcl-2 binding protein, is an evolutionarily conserved protein required for autophagy. The direct interaction between Beclin-1 and Bcl-2 or Bcl-xL provides a potential convergence point for apoptosis and autophagy, two programmed cell death processes. Given the functional significance of the interaction between Beclin-1 and Bcl-2/Bcl-xL, we performed detailed biochemical and structural characterizations of this interaction. We demonstrated that the Bcl-xL-binding domain of Beclin-1 contains a BH3 domain. Therefore, Beclin-1 is a new member of the BH3-only family proteins. The structure of Bcl-xL in complex with the Beclin-1 BH3 domain was determined at high resolution by NMR spectroscopy. Although similar to other known BH3 domains, the Beclin-1 BH3 domain displays its own distinct features in the complex with Bcl-xL. Systematic analysis of all known Bcl-xL/BH3 domain complexes helped us to identify the molecular basis underlying the capacity of Bcl-xL to recognize diverse target sequences.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17659302}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17659302 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17659302}}
==About this Structure==
==About this Structure==
-
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].
+
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].
==Reference==
==Reference==
Line 31: Line 35:
[[Category: Bcl-2 family protein]]
[[Category: Bcl-2 family protein]]
[[Category: Beclin-1]]
[[Category: Beclin-1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:32:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:38:50 2008''

Revision as of 20:38, 27 July 2008

Image:2pon.png

Template:STRUCTURE 2pon

Solution structure of the Bcl-xL/Beclin-1 complex

Template:ABSTRACT PUBMED 17659302

About this Structure

2PON is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1., Feng W, Huang S, Wu H, Zhang M, J Mol Biol. 2007 Sep 7;372(1):223-35. Epub 2007 Jun 30. PMID:17659302

Page seeded by OCA on Sun Jul 27 23:38:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pon"
Personal tools