2pon

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2pon.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2pon.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2pon| PDB=2pon | SCENE= }}
{{STRUCTURE_2pon| PDB=2pon | SCENE= }}
-
'''Solution structure of the Bcl-xL/Beclin-1 complex'''
+
===Solution structure of the Bcl-xL/Beclin-1 complex===
-
==Overview==
+
<!--
-
Beclin-1, originally identified as a Bcl-2 binding protein, is an evolutionarily conserved protein required for autophagy. The direct interaction between Beclin-1 and Bcl-2 or Bcl-xL provides a potential convergence point for apoptosis and autophagy, two programmed cell death processes. Given the functional significance of the interaction between Beclin-1 and Bcl-2/Bcl-xL, we performed detailed biochemical and structural characterizations of this interaction. We demonstrated that the Bcl-xL-binding domain of Beclin-1 contains a BH3 domain. Therefore, Beclin-1 is a new member of the BH3-only family proteins. The structure of Bcl-xL in complex with the Beclin-1 BH3 domain was determined at high resolution by NMR spectroscopy. Although similar to other known BH3 domains, the Beclin-1 BH3 domain displays its own distinct features in the complex with Bcl-xL. Systematic analysis of all known Bcl-xL/BH3 domain complexes helped us to identify the molecular basis underlying the capacity of Bcl-xL to recognize diverse target sequences.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17659302}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17659302 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17659302}}
==About this Structure==
==About this Structure==
-
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].
+
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].
==Reference==
==Reference==
Line 31: Line 35:
[[Category: Bcl-2 family protein]]
[[Category: Bcl-2 family protein]]
[[Category: Beclin-1]]
[[Category: Beclin-1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:32:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:38:50 2008''

Revision as of 20:38, 27 July 2008

Image:2pon.png

Template:STRUCTURE 2pon

Solution structure of the Bcl-xL/Beclin-1 complex

Template:ABSTRACT PUBMED 17659302

About this Structure

2PON is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1., Feng W, Huang S, Wu H, Zhang M, J Mol Biol. 2007 Sep 7;372(1):223-35. Epub 2007 Jun 30. PMID:17659302

Page seeded by OCA on Sun Jul 27 23:38:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pon"
Personal tools