1wzy

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[[Image:1wzy.jpg|left|200px]]
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{{STRUCTURE_1wzy| PDB=1wzy | SCENE= }}
{{STRUCTURE_1wzy| PDB=1wzy | SCENE= }}
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'''Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative'''
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===Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative===
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==Overview==
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A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.
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(as it appears on PubMed at http://www.pubmed.gov), where 16242327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16242327}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:21:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:40:44 2008''

Revision as of 20:40, 27 July 2008

Image:1wzy.png

Template:STRUCTURE 1wzy

Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative

Template:ABSTRACT PUBMED 16242327

About this Structure

1WZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative., Kinoshita T, Warizaya M, Ohori M, Sato K, Neya M, Fujii T, Bioorg Med Chem Lett. 2006 Jan 1;16(1):55-8. Epub 2005 Oct 18. PMID:16242327

Page seeded by OCA on Sun Jul 27 23:40:44 2008

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