2olv

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{{STRUCTURE_2olv| PDB=2olv | SCENE= }}
{{STRUCTURE_2olv| PDB=2olv | SCENE= }}
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'''Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex'''
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===Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex===
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==Overview==
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Peptidoglycan glycosyltransferases (GTs) catalyze the polymerization step of cell-wall biosynthesis, are membrane-bound, and are highly conserved across all bacteria. Long considered the "holy grail" of antibiotic research, they represent an essential and easily accessible drug target for antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus. We have determined the 2.8 angstrom structure of a bifunctional cell-wall cross-linking enzyme, including its transpeptidase and GT domains, both unliganded and complexed with the substrate analog moenomycin. The peptidoglycan GTs adopt a fold distinct from those of other GT classes. The structures give insight into critical features of the catalytic mechanism and key interactions required for enzyme inhibition.
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(as it appears on PubMed at http://www.pubmed.gov), where 17347437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17347437}}
==About this Structure==
==About this Structure==
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[[Category: Lysozyme fold]]
[[Category: Lysozyme fold]]
[[Category: Transpeptidase fold]]
[[Category: Transpeptidase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:11:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:41:14 2008''

Revision as of 20:41, 27 July 2008

Image:2olv.png

Template:STRUCTURE 2olv

Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex

Template:ABSTRACT PUBMED 17347437

About this Structure

2OLV is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis., Lovering AL, de Castro LH, Lim D, Strynadka NC, Science. 2007 Mar 9;315(5817):1402-5. PMID:17347437

Page seeded by OCA on Sun Jul 27 23:41:14 2008

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