1w3m

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[[Image:1w3m.gif|left|200px]]
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{{Seed}}
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[[Image:1w3m.png|left|200px]]
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{{STRUCTURE_1w3m| PDB=1w3m | SCENE= }}
{{STRUCTURE_1w3m| PDB=1w3m | SCENE= }}
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'''CRYSTAL STRUCTURE OF TSUSHIMYCIN'''
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===CRYSTAL STRUCTURE OF TSUSHIMYCIN===
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==Overview==
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The amphomycin derivative tsushimycin has been crystallized and its structure determined at 1.0 A resolution. The asymmetric unit contains 12 molecules and with 1300 independent atoms this structure is one of the largest solved using ab initio direct methods. The antibiotic is comprised of a cyclodecapeptide core, an exocyclic amino acid and a fatty-acid residue. Its backbone adopts a saddle-like conformation that is stabilized by a Ca2+ ion bound within the peptide ring and accounts for the Ca2+-dependence of this antibiotic class. Additional Ca2+ ions link the antibiotic molecules to dimers that enclose an empty space resembling a binding cleft. The dimers possess a large hydrophobic surface capable of interacting with the bacterial cell membrane. The antibiotic daptomycin may exhibit a similar conformation, as the amino-acid sequence is conserved at positions involved in Ca2+ binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_16041082}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16041082 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16041082}}
==About this Structure==
==About this Structure==
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[[Category: Daptomycin]]
[[Category: Daptomycin]]
[[Category: Lipopetide]]
[[Category: Lipopetide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:06:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:43:15 2008''

Revision as of 20:43, 27 July 2008

Image:1w3m.png

Template:STRUCTURE 1w3m

CRYSTAL STRUCTURE OF TSUSHIMYCIN

Template:ABSTRACT PUBMED 16041082

About this Structure

1W3M is a Single protein structure of sequence from Actinoplanes friuliensis. Full crystallographic information is available from OCA.

Reference

Structure of the lipopeptide antibiotic tsushimycin., Bunkoczi G, Vertesy L, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1160-4. Epub 2005, Jul 20. PMID:16041082

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