1q1j

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{{STRUCTURE_1q1j| PDB=1q1j | SCENE= }}
{{STRUCTURE_1q1j| PDB=1q1j | SCENE= }}
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'''Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide'''
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===Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide===
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==Overview==
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447-52D is a human monoclonal antibody isolated from a heterohybridoma derived from an HIV-1-infected individual. This antibody recognizes the hypervariable gp120 V3 loop, and neutralizes both X4 and R5 primary isolates, making it one of the most effective anti-V3 antibodies characterized to date. The crystal structure of the 447-52D Fab in complex with a 16-mer V3 peptide at 2.5 A resolution reveals that the peptide beta hairpin forms a three-stranded mixed beta sheet with complementarity determining region (CDR) H3, with most of the V3 side chains exposed to solvent. Sequence specificity is conferred through interaction of the type-II turn (residues GPGR) at the apex of the V3 hairpin with the base of CDR H3. This novel mode of peptide-antibody recognition enables the antibody to bind to many different V3 sequences where only the GPxR core epitope is absolutely required.
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(as it appears on PubMed at http://www.pubmed.gov), where 14962380 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14962380}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: V3 loop]]
[[Category: V3 loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:45:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:44:18 2008''

Revision as of 20:44, 27 July 2008

Image:1q1j.png

Template:STRUCTURE 1q1j

Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide

Template:ABSTRACT PUBMED 14962380

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D., Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA, Structure. 2004 Feb;12(2):193-204. PMID:14962380

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