2v9v

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{{STRUCTURE_2v9v| PDB=2v9v | SCENE= }}
{{STRUCTURE_2v9v| PDB=2v9v | SCENE= }}
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'''CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)'''
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===CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)===
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==Overview==
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The crystal structure of the first two winged-helix motifs of translation elongation factor SelB from Moorella thermoacetica has been determined at 1.1 A resolution. Compared with the previous structure of the two domains in conjunction with winged-helix modules 3 and 4, the first winged-helix domain underwent a substantial conformational change during which the alpha-helical and beta-sheet portions of the element opened up like a shell. This conformational rearrangement was elicited by a change in the orientation of Trp396, leading to the disclosure of a bona fide ligand-binding site in the direct vicinity of Trp396. Additionally, the C-terminal tail of the second domain followed a different path compared with the previous structure. It is conceivable that these conformational switches constitute part of the molecular mechanism that underlies the communication between the N-terminal part of SelB, which binds Sec-tRNA(Sec) and GTP, and the C-terminal part of the protein, which binds selenocysteine-insertion sequences.
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{{ABSTRACT_PUBMED_17881825}}
==About this Structure==
==About this Structure==
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[[Category: Transcription elongation factor selb]]
[[Category: Transcription elongation factor selb]]
[[Category: Winged-helix domain]]
[[Category: Winged-helix domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:27:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:45:47 2008''

Revision as of 20:45, 27 July 2008

Image:2v9v.png

Template:STRUCTURE 2v9v

CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)

Template:ABSTRACT PUBMED 17881825

About this Structure

2V9V is a Single protein structure of sequence from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB., Ganichkin O, Wahl MC, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1075-81. Epub 2007, Sep 19. PMID:17881825

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