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1qnk

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{{STRUCTURE_1qnk| PDB=1qnk | SCENE= }}
{{STRUCTURE_1qnk| PDB=1qnk | SCENE= }}
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'''TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES'''
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===TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES===
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==Overview==
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The three-dimensional structure of a novel four amino acid truncated form of the CXC chemokine GRObeta [5-73] isolated from bone marrow stromal cells with potent hematopoietic and anti-infective activities has been determined by two-dimensional (1)H nuclear magnetic resonance (NMR) spectroscopy in solution. On the basis of 1878 upper distance constraints derived from nuclear Overhauser effects (NOE) and 314 dihedral angle constraints, a group of 20 conformers representing the solution structure of the human GRObeta [5-73] was computed with the program DYANA. At the concentrations used for NMR study, GRObeta [5-73] forms a dimer in solution that is architectured by a six-stranded antiparallel beta-sheet (residues 25 to 29, 39 to 44, 49 to 52) and a pair of helices (residues 58 to 68) with 2-fold symmetry, while the C terminus of the protein is disordered. The average of the pairwise root-mean-square deviations of individual NMR conformers relative to the mean coordinates for the backbone atoms N, C(alpha) and C' of residues 5 to 68 is 0.47 A. Overall, the global fold of GRObeta [5-73] is similar to that of the previously reported NMR structure of GROalpha and the NMR and X-ray structures of interleukin-8. Among these three CXC chemokines, GRObeta [5-73] is most similar in structure to GROalpha. Significant differences between GRObeta [5-73], GROalpha and interleukin-8 are in the N-terminal loop comprising residues 12 to 19. The N-terminal arm containing the conserved ELR motif and the loop of residues 30 to 38 containing the GPH motif are different among these three CXC chemokines. The structural differences in these two regions may be responsible for the specificity of the receptor binding and biological activity of different chemokines.
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(as it appears on PubMed at http://www.pubmed.gov), where 10600366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10600366}}
==About this Structure==
==About this Structure==
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1QNK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA].
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1QNK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA].
==Reference==
==Reference==
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[[Category: Chemokine 15-o]]
[[Category: Chemokine 15-o]]
[[Category: Cxc chemokine]]
[[Category: Cxc chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:29:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:57:51 2008''

Revision as of 20:57, 27 July 2008

Image:1qnk.png

Template:STRUCTURE 1qnk

TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 10600366

About this Structure

1QNK is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8., Qian YQ, Johanson KO, McDevitt P, J Mol Biol. 1999 Dec 17;294(5):1065-72. PMID:10600366

Page seeded by OCA on Sun Jul 27 23:57:51 2008

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