1u33

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[[Image:1u33.gif|left|200px]]
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{{Seed}}
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[[Image:1u33.png|left|200px]]
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{{STRUCTURE_1u33| PDB=1u33 | SCENE= }}
{{STRUCTURE_1u33| PDB=1u33 | SCENE= }}
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'''In situ extension as an approach for identifying novel alpha-amylase inhibitors'''
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===In situ extension as an approach for identifying novel alpha-amylase inhibitors===
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==Overview==
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A new approach for the discovery and subsequent structural elucidation of oligosaccharide-based inhibitors of alpha-amylases based upon autoglucosylation of known alpha-glucosidase inhibitors is presented. This concept, highly analogous to what is hypothesized to occur with acarbose, is demonstrated with the known alpha-glucosidase inhibitor, d-gluconohydroximino-1,5-lactam. This was transformed from an inhibitor of human pancreatic alpha-amylase with a K(i) value of 18 mm to a trisaccharide analogue with a K(i) value of 25 mum. The three-dimensional structure of this complex was determined by x-ray crystallography and represents the first such structure determined with this class of inhibitors in any alpha-glycosidase. This approach to the discovery and structural analysis of amylase inhibitors should be generally applicable to other endoglucosidases and readily adaptable to a high throughput format.
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(as it appears on PubMed at http://www.pubmed.gov), where 15304511 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15304511}}
==About this Structure==
==About this Structure==
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[[Category: Human pancreatic alpha-amylase]]
[[Category: Human pancreatic alpha-amylase]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:58:29 2008''

Revision as of 20:58, 27 July 2008

Image:1u33.png

Template:STRUCTURE 1u33

In situ extension as an approach for identifying novel alpha-amylase inhibitors

Template:ABSTRACT PUBMED 15304511

About this Structure

1U33 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

In situ extension as an approach for identifying novel alpha-amylase inhibitors., Numao S, Damager I, Li C, Wrodnigg TM, Begum A, Overall CM, Brayer GD, Withers SG, J Biol Chem. 2004 Nov 12;279(46):48282-91. Epub 2004 Aug 10. PMID:15304511

Page seeded by OCA on Sun Jul 27 23:58:29 2008

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