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2nmq

From Proteopedia

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[[Image:2nmq.gif|left|200px]]
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{{STRUCTURE_2nmq| PDB=2nmq | SCENE= }}
{{STRUCTURE_2nmq| PDB=2nmq | SCENE= }}
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'''Simultaneous determination of protein structure and dynamics using rdcs'''
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===Simultaneous determination of protein structure and dynamics using rdcs===
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==Overview==
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Determination of protein structure classically results in a single average configuration that takes no account of conformational fluctuation. Dynamics are, however, inherently linked to structure and crucial to our understanding of biological function. In this study we have used analytical descriptions of dynamic averaging of residual dipolar couplings (RDCs) to simultaneously determine the backbone structure and dynamics of protein GB3. RDCs alone are used to determine an ultrahigh-resolution structure that compares very closely with a refined X-ray structure (rmsd of 0.34 A overall backbone residues). Dynamic amplitudes reporting on motions up to the millisecond time scale reproduce the main characteristics of dynamics previously determined in conjunction with the crystal structure. The use of RDCs alone allows a bias-free comparison with a purely static approach to structure determination. Extensive cross validation clearly demonstrates that the dynamic description is superior to the static approximation. The demonstration that this level of structural resolution and dynamic detail can be extracted from RDCs supports previous indications that these parameters contain extremely precise information about biomolecular conformational sampling.
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(as it appears on PubMed at http://www.pubmed.gov), where 17117856 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17117856}}
==About this Structure==
==About this Structure==
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2NMQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NMQ OCA].
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2NMQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NMQ OCA].
==Reference==
==Reference==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Simultaneous structure and dynamic]]
[[Category: Simultaneous structure and dynamic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:58:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:59:42 2008''

Revision as of 20:59, 27 July 2008

Image:2nmq.png

Template:STRUCTURE 2nmq

Simultaneous determination of protein structure and dynamics using rdcs

Template:ABSTRACT PUBMED 17117856

About this Structure

2NMQ is a Single protein structure of sequence from Bacteria. Full experimental information is available from OCA.

Reference

Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings., Bouvignies G, Markwick P, Bruschweiler R, Blackledge M, J Am Chem Soc. 2006 Nov 29;128(47):15100-1. PMID:17117856

Page seeded by OCA on Sun Jul 27 23:59:42 2008

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