1x0x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1x0x.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1x0x.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1x0x| PDB=1x0x | SCENE= }}
{{STRUCTURE_1x0x| PDB=1x0x | SCENE= }}
-
'''Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD'''
+
===Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD===
-
==Overview==
+
<!--
-
Homo sapiens L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1) catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate. The GPD1 protein was expressed in Escherichia coli, and purified as a fusion protein with glutathione S-transferase. Here we report the apoenzyme structure of GPD1 determined by multiwavelength anomalous diffraction phasing, and other complex structures with small molecules (NAD+ and DHAP) by the molecular replacement method. This enzyme structure is organized into two distinct domains, the N-terminal eight-stranded beta-sheet sandwich domain and the C-terminal helical substrate-binding domain. An electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analyses. In addition, the inhibitory effects of zinc and sulfate on GPDHs are assayed and discussed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16460752}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16460752 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16460752}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Gpd1]]
[[Category: Gpd1]]
[[Category: Nad]]
[[Category: Nad]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:23:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:01:00 2008''

Revision as of 21:01, 27 July 2008

Image:1x0x.png

Template:STRUCTURE 1x0x

Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD

Template:ABSTRACT PUBMED 16460752

About this Structure

1X0X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)., Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M, Rao Z, J Mol Biol. 2006 Mar 31;357(3):858-69. Epub 2006 Jan 18. PMID:16460752

Page seeded by OCA on Mon Jul 28 00:01:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x0x"
Personal tools