2ns5

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{{STRUCTURE_2ns5| PDB=2ns5 | SCENE= }}
{{STRUCTURE_2ns5| PDB=2ns5 | SCENE= }}
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'''The conserved N-terminal domain of Par-3 adopts a novel PB1-like structure required for Par-3 oligomerization and apical membrane localization'''
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===The conserved N-terminal domain of Par-3 adopts a novel PB1-like structure required for Par-3 oligomerization and apical membrane localization===
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==Overview==
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The evolutionarily conserved Par-3/Par-6/aPKC complex is essential for the establishment and maintenance of polarity of a wide range of cells. Both Par-3 and Par-6 are PDZ domain containing scaffold proteins capable of binding to polarity regulatory proteins. In addition to three PDZ domains, Par-3 also contains a conserved N-terminal oligomerization domain (NTD) that is essential for proper subapical membrane localization and consequently the functions of Par-3. The molecular basis of NTD-mediated Par-3 membrane localization is poorly understood. Here, we describe the structure of a monomeric form of the Par-3 NTD. Unexpectedly, the domain adopts a PB1-like fold with both type-I and type-II structural features. The Par-3 NTD oligomerizes into helical filaments via front-to-back interactions. We further demonstrate that the NTD-mediated membrane localization of Par-3 in MDCK cells is solely attributed to its oligomerization capacity. The data presented in this study suggest that the Par-3 NTD is likely to facilitate the assembly of higher-order Par-3/Par-6/aPKC complex with increased avidities in targeting the complex to the subapical membrane domain and in binding to other polarity-regulating proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17476308 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17476308}}
==About this Structure==
==About this Structure==
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2NS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS5 OCA].
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2NS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS5 OCA].
==Reference==
==Reference==
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[[Category: Pb1 domain]]
[[Category: Pb1 domain]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:01:10 2008''

Revision as of 21:01, 27 July 2008

Image:2ns5.png

Template:STRUCTURE 2ns5

The conserved N-terminal domain of Par-3 adopts a novel PB1-like structure required for Par-3 oligomerization and apical membrane localization

Template:ABSTRACT PUBMED 17476308

About this Structure

2NS5 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization., Feng W, Wu H, Chan LN, Zhang M, EMBO J. 2007 Jun 6;26(11):2786-96. Epub 2007 May 3. PMID:17476308

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