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2dgc

From Proteopedia

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[[Image:2dgc.gif|left|200px]]
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{{STRUCTURE_2dgc| PDB=2dgc | SCENE= }}
{{STRUCTURE_2dgc| PDB=2dgc | SCENE= }}
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'''GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB SITE DNA'''
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===GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB SITE DNA===
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==Overview==
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The X-ray structure of the GCN4-bZIP protein bound to DNA containing the ATF/CREB recognition sequence has been refined at 2.2 A. The water-mediated interactions between the basic domain and DNA are revealed, and combined with a more accurate description of the direct contacts, further clarify how binding specificity is achieved. Water molecules extend the interactions of both invariant basic domain residues, asparagine 235 and arginine 243, beyond their direct base contacts. The slight bending of the basic domain alpha-helix around the DNA facilitates the linking of arginine 241, 243 and 245 to main-chain carbonyl oxygen atoms via water molecules, apparently stabilizing interactions with the DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 7500340 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7500340}}
==About this Structure==
==About this Structure==
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[[Category: Eukaryotic regulatory protein]]
[[Category: Eukaryotic regulatory protein]]
[[Category: Leucine zipper]]
[[Category: Leucine zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:22:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:01:54 2008''

Revision as of 21:01, 27 July 2008

Image:2dgc.png

Template:STRUCTURE 2dgc

GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB SITE DNA

Template:ABSTRACT PUBMED 7500340

About this Structure

2DGC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bZIP/DNA complex at 2.2 A: determinants of DNA specific recognition., Keller W, Konig P, Richmond TJ, J Mol Biol. 1995 Dec 8;254(4):657-67. PMID:7500340

Page seeded by OCA on Mon Jul 28 00:01:54 2008

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