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2qvs

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{{STRUCTURE_2qvs| PDB=2qvs | SCENE= }}
{{STRUCTURE_2qvs| PDB=2qvs | SCENE= }}
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'''Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase'''
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===Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase===
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==Overview==
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The catalytic (C) subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is inhibited by two classes of regulatory subunits, RI and RII. The RII subunits are substrates as well as inhibitors and do not require adenosine triphosphate (ATP) to form holoenzyme, which distinguishes them from RI subunits. To understand the molecular basis for isoform diversity, we solved the crystal structure of an RIIalpha holoenzyme and compared it to the RIalpha holoenzyme. Unphosphorylated RIIalpha(90-400), a deletion mutant, undergoes major conformational changes as both of the cAMP-binding domains wrap around the C subunit's large lobe. The hallmark of this conformational reorganization is the helix switch in domain A. The C subunit is in an open conformation, and its carboxyl-terminal tail is disordered. This structure demonstrates the conserved and isoform-specific features of RI and RII and the importance of ATP, and also provides a new paradigm for designing isoform-specific activators or antagonists for PKA.
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(as it appears on PubMed at http://www.pubmed.gov), where 17932298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17932298}}
==About this Structure==
==About this Structure==
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[[Category: Transferase/transferase regulator complex]]
[[Category: Transferase/transferase regulator complex]]
[[Category: Type iia holoenzyme]]
[[Category: Type iia holoenzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:02:40 2008''

Revision as of 21:02, 27 July 2008

Image:2qvs.png

Template:STRUCTURE 2qvs

Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase

Template:ABSTRACT PUBMED 17932298

About this Structure

2QVS is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity., Wu J, Brown SH, von Daake S, Taylor SS, Science. 2007 Oct 12;318(5848):274-9. PMID:17932298

Page seeded by OCA on Mon Jul 28 00:02:40 2008

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