1pwa

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[[Image:1pwa.gif|left|200px]]
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{{Seed}}
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[[Image:1pwa.png|left|200px]]
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{{STRUCTURE_1pwa| PDB=1pwa | SCENE= }}
{{STRUCTURE_1pwa| PDB=1pwa | SCENE= }}
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'''Crystal structure of Fibroblast Growth Factor 19'''
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===Crystal structure of Fibroblast Growth Factor 19===
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==Overview==
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The 22 members of the FGF family have been implicated in cell proliferation, differentiation, survival, and migration. They are required for both development and maintenance of vertebrates, demonstrating an exquisite pattern of affinities for both protein and proteoglycan receptors. FGF19, one of the most divergent human FGFs, is unique in binding solely to one receptor, FGFR4. We have used molecular replacement to solve the crystal structure of FGF19 at 1.3 A resolution using five superimposed FGF structures as the search model. The structure shows that two novel disulfide bonds found in FGF19, one of which appears to be conserved among several of the other FGFs, stabilize extended loops. The key heparin-binding loops of FGF19 have radically different conformations and charge patterns, compared to other FGFs, correlating with the unusually low affinity of FGF19 for heparin. A model for the complex of FGF19 with FGFR4 demonstrates that unique sequences in both FGF19 and FGFR4 are key to the formation of the complex. The structure therefore offers a clear explanation for the unusual affinity of FGF19 for FGFR4 alone.
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The line below this paragraph, {{ABSTRACT_PUBMED_14730967}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14730967 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14730967}}
==About this Structure==
==About this Structure==
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[[Category: Beta trefoil]]
[[Category: Beta trefoil]]
[[Category: Disulphide bond]]
[[Category: Disulphide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:33:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:04:13 2008''

Revision as of 21:04, 27 July 2008

Image:1pwa.png

Template:STRUCTURE 1pwa

Crystal structure of Fibroblast Growth Factor 19

Template:ABSTRACT PUBMED 14730967

About this Structure

1PWA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity., Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL, Biochemistry. 2004 Jan 27;43(3):629-40. PMID:14730967

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