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2nps

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{{STRUCTURE_2nps| PDB=2nps | SCENE= }}
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'''Crystal Structure of the Early Endosomal SNARE Complex'''
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===Crystal Structure of the Early Endosomal SNARE Complex===
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==Overview==
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SNARE proteins mediate membrane fusion in eukaryotic cells. They contain conserved SNARE motifs that are usually located adjacent to a C-terminal transmembrane domain. SNARE motifs spontaneously assemble into four helix bundles, with each helix belonging to a different subfamily. Liposomes containing SNAREs spontaneously fuse with each other, but it is debated how the SNAREs are distributed between the membranes. Here, we report that the SNAREs mediating homotypic fusion of early endosomes fuse liposomes in five out of seven possible combinations, in contrast to previously studied SNAREs involved in heterotypic fusion events. The crystal structure of the early endosomal SNARE complex resembles that of the neuronal and late endosomal complexes, but differs in surface side-chain interactions. We conclude that homotypic fusion reactions may proceed with multiple SNARE topologies, suggesting that the conserved SNARE structure allows for flexibility in the initial interactions needed for fusion.
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{{ABSTRACT_PUBMED_17159904}}
==About this Structure==
==About this Structure==
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[[Category: Vesicle fusion]]
[[Category: Vesicle fusion]]
[[Category: Vti1a]]
[[Category: Vti1a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:45:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:08:16 2008''

Revision as of 21:08, 27 July 2008

Image:2nps.png


PDB ID 2nps

Drag the structure with the mouse to rotate
2nps, resolution 2.50Å ()
Gene: Vamp4_predicted (Mus musculus), syntaxin 13 (Rattus norvegicus), Vti1a (Rattus norvegicus), STX6 (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Early Endosomal SNARE Complex

Template:ABSTRACT PUBMED 17159904

About this Structure

2NPS is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies., Zwilling D, Cypionka A, Pohl WH, Fasshauer D, Walla PJ, Wahl MC, Jahn R, EMBO J. 2007 Jan 10;26(1):9-18. Epub 2006 Dec 7. PMID:17159904

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