2pkg

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[[Image:2pkg.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2pkg| PDB=2pkg | SCENE= }}
{{STRUCTURE_2pkg| PDB=2pkg | SCENE= }}
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'''Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40'''
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===Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40===
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==Overview==
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The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B' for the PP2A core enzyme. Consequently, ST does not efficiently displace B' from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_17529992}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17529992 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17529992}}
==About this Structure==
==About this Structure==
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[[Category: Small t antigen]]
[[Category: Small t antigen]]
[[Category: Sv40]]
[[Category: Sv40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:17:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:10:16 2008''

Revision as of 21:10, 27 July 2008

Image:2pkg.png

Template:STRUCTURE 2pkg

Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40

Template:ABSTRACT PUBMED 17529992

About this Structure

2PKG is a Protein complex structure of sequences from Homo sapiens and Simian virus 40. Full crystallographic information is available from OCA.

Reference

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40., Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y, Nat Struct Mol Biol. 2007 Jun;14(6):527-34. Epub 2007 May 27. PMID:17529992

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