1wbl

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{{STRUCTURE_1wbl| PDB=1wbl | SCENE= }}
{{STRUCTURE_1wbl| PDB=1wbl | SCENE= }}
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'''WINGED BEAN LECTIN COMPLEXED WITH METHYL-ALPHA-D-GALACTOSE'''
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===WINGED BEAN LECTIN COMPLEXED WITH METHYL-ALPHA-D-GALACTOSE===
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==Overview==
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The structure of basic Winged Bean Agglutinin (WBAI) with two dimeric molecules complexed with methyl-alpha-D-galactopyranoside in the asymmetric unit, has been determined by the molecular replacement method and refined with 2.5 A X-ray intensity data. The polypeptide chain of each monomer has the characteristic legume lectin tertiary fold. The structure clearly defines the lectin-carbohydrate interactions. It reveals how the unusually long variable loop in the binding region endows the lectin with its characteristic sugar specificity. The lectin forms non-canonical dimers of the type found in Erythrina corallodendron lectin (EcorL) even though glycosylation, unlike in EcorL, does not prevent the formation of canonical dimers. The structure thus further demonstrates that the mode of dimerisation of legume lectins is not necessarily determined by the covalently bound carbohydrate but is governed by features intrinsic to the protein. The present analysis and our earlier work on peanut lectin (PNA), show that legume lectins are a family of proteins in which small alterations in essentially the same tertiary structure lead to wide variations in quaternary association. A relationship among the non-canonical modes of dimeric association in legume lectins is presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 9500920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9500920}}
==About this Structure==
==About this Structure==
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[[Category: Legume lectin]]
[[Category: Legume lectin]]
[[Category: Quaternary association]]
[[Category: Quaternary association]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:11:05 2008''

Revision as of 21:11, 27 July 2008

Image:1wbl.png

Template:STRUCTURE 1wbl

WINGED BEAN LECTIN COMPLEXED WITH METHYL-ALPHA-D-GALACTOSE

Template:ABSTRACT PUBMED 9500920

About this Structure

1WBL is a Single protein structure of sequence from Psophocarpus tetragonolobus. Full crystallographic information is available from OCA.

Reference

Carbohydrate specificity and quaternary association in basic winged bean lectin: X-ray analysis of the lectin at 2.5 A resolution., Prabu MM, Sankaranarayanan R, Puri KD, Sharma V, Surolia A, Vijayan M, Suguna K, J Mol Biol. 1998 Mar 6;276(4):787-96. PMID:9500920

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