1r4r

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[[Image:1r4r.gif|left|200px]]
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{{STRUCTURE_1r4r| PDB=1r4r | SCENE= }}
{{STRUCTURE_1r4r| PDB=1r4r | SCENE= }}
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'''Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA'''
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===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA===
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==Overview==
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Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity.
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(as it appears on PubMed at http://www.pubmed.gov), where 1865905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1865905}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Steroid receptor]]
[[Category: Steroid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:13:42 2008''

Revision as of 21:13, 27 July 2008

Image:1r4r.png

Template:STRUCTURE 1r4r

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

Template:ABSTRACT PUBMED 1865905

About this Structure

1R4R is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA., Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB, Nature. 1991 Aug 8;352(6335):497-505. PMID:1865905

Page seeded by OCA on Mon Jul 28 00:13:42 2008

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