2rii

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{{STRUCTURE_2rii| PDB=2rii | SCENE= }}
{{STRUCTURE_2rii| PDB=2rii | SCENE= }}
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'''Crystal Structure of Human Peroxiredoxin I in complex with Sulfiredoxin'''
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===Crystal Structure of Human Peroxiredoxin I in complex with Sulfiredoxin===
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==Overview==
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Typical 2-Cys peroxiredoxins (Prxs) have an important role in regulating hydrogen peroxide-mediated cell signalling. In this process, Prxs can become inactivated through the hyperoxidation of an active site Cys residue to Cys sulphinic acid. The unique repair of this moiety by sulphiredoxin (Srx) restores peroxidase activity and terminates the signal. The hyperoxidized form of Prx exists as a stable decameric structure with each active site buried. Therefore, it is unclear how Srx can access the sulphinic acid moiety. Here we present the 2.6 A crystal structure of the human Srx-PrxI complex. This complex reveals the complete unfolding of the carboxy terminus of Prx, and its unexpected packing onto the backside of Srx away from the Srx active site. Binding studies and activity analyses of site-directed mutants at this interface show that the interaction is required for repair to occur. Moreover, rearrangements in the Prx active site lead to a juxtaposition of the Prx Gly-Gly-Leu-Gly and Srx ATP-binding motifs, providing a structural basis for the first step of the catalytic mechanism. The results also suggest that the observed interactions may represent a common mode for other proteins to bind to Prxs.
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(as it appears on PubMed at http://www.pubmed.gov), where 18172504 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18172504}}
==About this Structure==
==About this Structure==
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[[Category: Redox-active center]]
[[Category: Redox-active center]]
[[Category: Sulfinic acid reductase]]
[[Category: Sulfinic acid reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:58:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:14:03 2008''

Revision as of 21:14, 27 July 2008

Image:2rii.png

Template:STRUCTURE 2rii

Crystal Structure of Human Peroxiredoxin I in complex with Sulfiredoxin

Template:ABSTRACT PUBMED 18172504

About this Structure

2RII is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace., Jonsson TJ, Johnson LC, Lowther WT, Nature. 2008 Jan 3;451(7174):98-101. PMID:18172504

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