2hc8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hc8.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2hc8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hc8| PDB=2hc8 | SCENE= }}
{{STRUCTURE_2hc8| PDB=2hc8 | SCENE= }}
-
'''Structure of the A. fulgidus CopA A-domain'''
+
===Structure of the A. fulgidus CopA A-domain===
-
==Overview==
+
<!--
-
Copper homeostasis is maintained in part by membrane-bound P(1B)-type ATPases that are found in all organisms and drive the transport of this essential, yet toxic, metal ion across cellular membranes. CopA from Archaeoglobus fulgidus is a hyperthermophilic member of this ATPase subfamily and is homologous to the human Wilson and Menkes disease ATPases. To gain insight into Cu(+)-ATPase function, the structure of the CopA actuator domain (A-domain) was determined to 1.65 A resolution. The CopA A-domain functions to couple ATP hydrolysis in the ATP binding domain (ATPBD) with structural rearrangements of critical transmembrane segments. Its fold is quite similar to that of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1) A-domain, with the exception of an external loop region. On the basis of sequence and structural comparisons, specific residues that probably interact with the CopA ATPBD have been identified. Comparisons to the Wilson and Menkes disease A-domains reveal the presence of an additional loop that may be associated with regulatory functions in eukaryotic Cu(+)-ATPases. Finally, several mutations in the Wilson and Menkes disease ATPases occur in the A-domain, and their likely effects on function can be inferred from the CopA A-domain structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16906753}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16906753 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16906753}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Copb]]
[[Category: Copb]]
[[Category: Copper]]
[[Category: Copper]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:06:47 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:14:34 2008''

Revision as of 21:14, 27 July 2008

Image:2hc8.png

Template:STRUCTURE 2hc8

Structure of the A. fulgidus CopA A-domain

Template:ABSTRACT PUBMED 16906753

About this Structure

2HC8 is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Structure of the actuator domain from the Archaeoglobus fulgidus Cu(+)-ATPase., Sazinsky MH, Agarwal S, Arguello JM, Rosenzweig AC, Biochemistry. 2006 Aug 22;45(33):9949-55. PMID:16906753

Page seeded by OCA on Mon Jul 28 00:14:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hc8"
Personal tools