1nqy

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{{Seed}}
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[[Image:1nqy.png|left|200px]]
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{{STRUCTURE_1nqy| PDB=1nqy | SCENE= }}
{{STRUCTURE_1nqy| PDB=1nqy | SCENE= }}
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'''The structure of a CoA pyrophosphatase from D. Radiodurans'''
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===The structure of a CoA pyrophosphatase from D. Radiodurans===
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==Overview==
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Gene Dr1184 from Deinococcus radiodurans codes for a Nudix enzyme (DR-CoAse) that hydrolyzes the pyrophosphate moiety of coenzyme A (CoA). Nudix enzymes with the same specificity have been found in yeast, humans, and mice. The three-dimensional structure of DR-CoAse, the first of a Nudix hydrolase with this specificity, reveals that this enzyme contains, in addition to the fold observed in other Nudix enzymes, insertions that are characteristic of a CoA-hydrolyzing Nudix subfamily. The structure of the complex of the enzyme with Mg(2+), its activating cation, reveals the position of the catalytic site. A helix, part of the N-terminal insertion, partially occludes the binding site and has to change its position to permit substrate binding. Comparison of the structure of DR-CoAse to those of other Nudix enzymes, together with the location in the structure of the sequence characteristic of CoAses, suggests a mode of binding of the substrate to the enzyme that is compatible with all available data.
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The line below this paragraph, {{ABSTRACT_PUBMED_12837785}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12837785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12837785}}
==About this Structure==
==About this Structure==
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[[Category: Nudix]]
[[Category: Nudix]]
[[Category: Pyrophosphatase]]
[[Category: Pyrophosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:52:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:16:32 2008''

Revision as of 21:16, 27 July 2008

Image:1nqy.png

Template:STRUCTURE 1nqy

The structure of a CoA pyrophosphatase from D. Radiodurans

Template:ABSTRACT PUBMED 12837785

About this Structure

1NQY is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family., Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM, J Bacteriol. 2003 Jul;185(14):4110-8. PMID:12837785

Page seeded by OCA on Mon Jul 28 00:16:32 2008

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