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1qf8

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[[Image:1qf8.jpg|left|200px]]
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{{Seed}}
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[[Image:1qf8.png|left|200px]]
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{{STRUCTURE_1qf8| PDB=1qf8 | SCENE= }}
{{STRUCTURE_1qf8| PDB=1qf8 | SCENE= }}
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'''TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS'''
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===TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS===
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==Overview==
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Protein kinase CK2 is a tetramer composed of two alpha catalytic subunits and two beta regulatory subunits. The structure of a C-terminal truncated form of the human beta subunit has been determined by X-ray crystallography to 1.7 A resolution. One dimer is observed in the asymmetric unit of the crystal. The most striking feature of the structure is the presence of a zinc finger mediating the dimerization. The monomer structure consists of two domains, one entirely alpha-helical and one including the zinc finger. The dimer has a crescent shape holding a highly acidic region at both ends. We propose that this acidic region is involved in the interactions with the polyamines and/or catalytic subunits. Interestingly, conserved amino acid residues among beta subunit sequences are clustered along one linear ridge that wraps around the entire dimer. This feature suggests that protein partners may interact with the dimer through a stretch of residues in an extended conformation.
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The line below this paragraph, {{ABSTRACT_PUBMED_10357806}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10357806 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10357806}}
==About this Structure==
==About this Structure==
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[[Category: Ser/thr protein kinase]]
[[Category: Ser/thr protein kinase]]
[[Category: Zn finger]]
[[Category: Zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:18 2008''

Revision as of 21:18, 27 July 2008

Image:1qf8.png

Template:STRUCTURE 1qf8

TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS

Template:ABSTRACT PUBMED 10357806

About this Structure

1QF8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization., Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O, EMBO J. 1999 Jun 1;18(11):2930-40. PMID:10357806

Page seeded by OCA on Mon Jul 28 00:18:18 2008

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