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1s9h

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[[Image:1s9h.gif|left|200px]]
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{{STRUCTURE_1s9h| PDB=1s9h | SCENE= }}
{{STRUCTURE_1s9h| PDB=1s9h | SCENE= }}
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'''Crystal Structure of Adeno-associated virus Type 2 Rep40'''
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===Crystal Structure of Adeno-associated virus Type 2 Rep40===
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==Overview==
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We report here the crystal structure of an SF3 DNA helicase, Rep40, from adeno-associated virus 2 (AAV2). We show that AAV2 Rep40 is structurally more similar to the AAA(+) class of cellular proteins than to DNA helicases from other superfamilies. The structure delineates the expected Walker A and B motifs, but also reveals an unexpected "arginine finger" that directly implies the requirement of Rep40 oligomerization for ATP hydrolysis and helicase activity. Further, the Rep40 AAA(+) domain is novel in that it is unimodular as opposed to bimodular. Altogether, the structural connection to AAA(+) proteins defines the general architecture of SF3 DNA helicases, a family that includes simian virus 40 (SV40) T antigen, as well as provides a conceptual framework for understanding the role of Rep proteins during AAV DNA replication, packaging, and site-specific integration.
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(as it appears on PubMed at http://www.pubmed.gov), where 12906833 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12906833}}
==About this Structure==
==About this Structure==
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[[Category: Walker some]]
[[Category: Walker some]]
[[Category: Walker b]]
[[Category: Walker b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:27:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:25:07 2008''

Revision as of 21:25, 27 July 2008

Image:1s9h.png

Template:STRUCTURE 1s9h

Crystal Structure of Adeno-associated virus Type 2 Rep40

Template:ABSTRACT PUBMED 12906833

About this Structure

1S9H is a Single protein structure of sequence from Adeno-associated virus 2. Full crystallographic information is available from OCA.

Reference

Crystal structure of the SF3 helicase from adeno-associated virus type 2., James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK, Structure. 2003 Aug;11(8):1025-35. PMID:12906833

Page seeded by OCA on Mon Jul 28 00:25:07 2008

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